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Enhancing the mental well-being of postmenopausal women using ExoTMS®

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Received: 10 December 2025
Published: 26 January 2026
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Mental well-being may be adversely affected during menopause. This study examines the effects of a novel ExoTMS® technology on its improvement. Postmenopausal female participants (n=14; 61.8±7.8 years; body mass index: 22.5±2.5 kg/m2) were retrospectively selected from a multi-center study. Participants underwent four transcranial magnetic stimulation (TMS) sessions. Evaluation was performed using the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS), Subject Satisfaction and Mental Wellness Questionnaire, and Therapy Comfort Questionnaire. WEMWBS significantly increased (p=0.001) from a baseline of 54.4±9.4 (moderate well-being) to 62.8±8.8 (high well-being) at 3 months post-treatment. 92.9% of participants reported feeling happier and experiencing greater mental energy. All participants reported feeling less stressed and found the treatment comfortable. These findings suggest that ExoTMS may serve as an effective intervention for enhancing mental well-being in postmenopausal women.

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American Psychology Association. Mental Health. Available from: https://www.apa.org/topics/mental-health.

Mishra GD, Brown WJ, Dobson AJ. Physical and mental health: changes during menopause transition. Qual Life Res 2003;12:405-12. DOI: https://doi.org/10.1023/A:1023421128141

WHO. Menopause. 2024. Available from: https://www.who.int/news-room/fact-sheets/detail/menopause.

Ma XY, Wang YJ, Xu B, et al. Near-infrared spectroscopy reveals abnormal hemodynamics in the left dorsolateral prefrontal cortex of menopausal depression patients. Dis Markers 2017;2017:1695930. DOI: https://doi.org/10.1155/2017/1695930

Keenan PA, Ezzat WH, Ginsburg K, Moore GJ. Prefrontal cortex as the site of estrogen’s effect on cognition. Psychoneuroendocrinology 2001;26:577-90. DOI: https://doi.org/10.1016/S0306-4530(01)00013-0

Freeman EW. Associations of depression with the transition to menopause. Menopause 2010;17:823-7. DOI: https://doi.org/10.1097/gme.0b013e3181db9f8b

Gautam S, Jain A, Chaudhary J, et al. Concept of mental health and mental well-being, it’s determinants and coping strategies. Indian J Psychiatry 2024;66:S231-44. DOI: https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_707_23

Barbey AK, Koenigs M, Grafman J. Dorsolateral prefrontal contributions to human working memory. Cortex 2013;49:1195-205. DOI: https://doi.org/10.1016/j.cortex.2012.05.022

Nejati V, Majdi R, Salehinejad MA, Nitsche MA. The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions. Sci Rep 2021;11:1971. DOI: https://doi.org/10.1038/s41598-021-81454-7

Klomjai W, Katz R, Lackmy-Vallée A. Basic principles of transcranial magnetic stimulation (TMS) and repetitive TMS (rTMS). Ann Phys Rehabil Med 2015;58:208-13. DOI: https://doi.org/10.1016/j.rehab.2015.05.005

Dees M, Halaas Y, McCoy JD. ExoTMSTM technology: a novel breakthrough in transcranial magnetic stimulation for enhancing mental well-being. J Psychiatry Psychiatr Disord 2025;9:245-54. DOI: https://doi.org/10.26502/jppd.2572-519X0255

Huang CC, Wei IH, Chou YH, Su TP. Effect of age, gender, menopausal status, and ovarian hormonal level on rTMS in treatment-resistant depression. Psychoneuroendocrinology 2008;33:821-31. DOI: https://doi.org/10.1016/j.psyneuen.2008.03.006

Urry HL, Nitschke JB, Dolski I, et al. Making a life worth living: neural correlates of well-being. Psychol Sci 2004;15:367-72. DOI: https://doi.org/10.1111/j.0956-7976.2004.00686.x

Heller AS, van Reekum CM, Schaefer SM, et al. Sustained striatal activity predicts eudaimonic well-being and cortisol output. Psychol Sci 2013;24:2191-200. DOI: https://doi.org/10.1177/0956797613490744

Lan MJ, Chhetry BT, Liston C, et al. Transcranial magnetic stimulation of left dorsolateral prefrontal cortex induces brain morphological changes in regions associated with a treatment resistant major depressive episode; an exploratory analysis. Brain Stimulat 2016;9:577-83. DOI: https://doi.org/10.1016/j.brs.2016.02.011

Rivas-Grajales AM, Barbour T, Camprodon JA, Kritzer MD. The impact of sex hormones on transcranial magnetic stimulation measures of cortical excitability: a systematic review and considerations for clinical practice. Harv Rev Psychiatry 2023;31:114-23. DOI: https://doi.org/10.1097/HRP.0000000000000366

Hsu TW, Yeh TC, Kao YC, et al. The dose-effect relationship of six stimulation parameters with rTMS over left DLPFC on treatment-resistant depression: a systematic review and meta-analysis. Neurosci Biobehav Rev 2024;162:105704. DOI: https://doi.org/10.1016/j.neubiorev.2024.105704

Ryff CD. Psychological well-being revisited: advances in the science and practice of eudaimonia. Psychother Psychosom 2014;83:10-28. DOI: https://doi.org/10.1159/000353263

Diener E, Pressman SD, Hunter J, Delgadillo-Chase D. If, why, and when subjective well-being influences health, and future needed research. Appl Psychol Health Well-Being 2017;9:133-67. DOI: https://doi.org/10.1111/aphw.12090

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1.
Enhancing the mental well-being of postmenopausal women using ExoTMS®. Mental Wellness [Internet]. 2026 Jan. 26 [cited 2026 Sep. 18];4. Available from: https://www.mental-wellness-journal.net/mw/article/view/34